Overall, you can safely delete almost everything in Disk Cleanup as long as you don’t plan on rolling back a device driver, uninstalling an update, or troubleshooting a system problem. But you should probably steer clear of those “Windows ESD Installation files” unless you’re really hurting for space.
What happens if I clean up system files?
Disk Cleanup helps free up space on your hard disk, creating improved system performance. Disk Cleanup searches your disk and then shows you temporary files, Internet cache files, and unnecessary program files that you can safely delete. You can direct Disk Cleanup to delete some or all of those files.
Is it OK to clean Windows Update cleanup?
When you install updates from Windows Update, Windows keeps older versions of the system files around. This allows you to uninstall the updates later and troubleshoot update-related issues. These files are safe to delete in most cases.
Is it good to do Disk Cleanup?
Removing unnecessary files, including temporary files, helps speed up and improve the performance of the hard drive and computer. Running Disk Cleanup at least once a month is an excellent maintenance task and frequency.